How to Use Manual Saves
You can make use of manual saves. You can’t save when in the midst of a BT encounter, but if you keep track of the monsters on your map (once you get the ability to track the weather), or know they’re coming, you can save just before entering BT territory. That’s when you save. This also helps if you plan to pull off a risky maneuver — like crossing a deep river or sliding down a mountain. If you botch your plan, simply reload.
In order to manually save, pause the game and head down to the “System” menu. Then just select save. You can’t save while riding inside a vehicle or during BT and MULE encounters, however. Keep that in mind!